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[7] AANAT activity follows a circadian rhythm driven by cAMP-responsive transcription, and its expression is suppressed in aged pineal tissue through mechanisms that parallel the epigenetic silencing observed at the hTERT locus suggesting a common chromatin remodeling mechanism may underlie both effects

Morales DK, Grahl N, Okegbe C, Dietrich LE, Jacobs NJ, Hogan DA