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Experimental methods Chemicals and reagents High-performance liquid chromatography-grade methanol, water, and acetonitrile were purchased from J.T

These biomarkers identify contraindications and guide starting dose, titration pace, and monitoring intervals throughout treatment

Materials and methods Contractile studies on human preparations The bathing solution of the organ baths contained 119.8 mM NaCl, 5.4 mM KCl, 1.8 mM CaCl 2 , 1.05 mM MgCl 2 , 0.42 mM NaH 2 PO 4 , 22.6 mM NaHCO 3 , 0.05 mM Na 2 EDTA, 0.28 mM ascorbic acid, and 5.05 mM glucose

All weight evidence is preclinical mouse and cell-culture work

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