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We do not yet have robust data specifically addressing lower-dose maintenance strategies
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For example, NMR-titration experiments of non-glutathionylated poplar GrxC4 or ScGrx8 with GSH required high glutathione concentrations to detect chemical shifts 47,48 (and titrations of active site serine mutants with GSSG cannot discriminate between both glutathionyl moieties)
Future frontiers for small-molecule agonists involve expanding therapeutic targets to include liver health, cardiovascular risk reduction, and inflammation control
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