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At least some compositions/formulation of the current technology can lessen the rebound effect, cardiovascular stress, addiction/abuse potential and/or other common stimulant side effects associated with amphetamine and similar compounds

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Those with active skin infections or open wounds

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Clearly, a reduction in MTHFR activity can alter DNA methylation, with research suggesting that individuals who are homozygous for the polymorphism (C677T) in the MTHFR gene have significantly lower levels of methylated DNA when their folate levels are also low