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Adrenal glands secrete the adrenal sex hormones (androstenedione, DHEAS), which in the adipose tissue could convert to more potent testosterone and exert a negative or positive feedback to the HPG axis

adults will qualify as obese by 2030 and nearly 25% as severely obese.i GLP-1s should be a key tool in managing obesity outcomes and costs: Despite higher prescription costs relative to nonusers, persistent GLP-1 use can decrease average annual total cost of care by $14K-$15K (14%) among chronically obese patients in the first one to two years of use

(PubMed) Cristofano A, Sapere N, La Marca G, et al

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doi:10.1038/s41584-025-01302-0