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Gomez-Santos C, Hernandez-Morante JJ, Margareto J, Larrarte E, Formiguera X, Martinez CM, et al
At the clinical strategy level, the establishment of quantifiable metabolic readouts, such as the Kyn/Trp ratio, the expression of key metabolic enzymes or transporters, and the proportions of signaling metabolites, combined with stratified interventions based on disease stage and tissue involvement, may help further promote tissue repair and restoration of immune homeostasis while suppressing inflammatory responses, thereby enabling treatment strategies for autoimmune diseases with greater long-term benefit (139)
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Research on obese mice showed that chronic AOD-9604 treatment reduced both subcutaneous and visceral fat mass, with visceral reductions being proportionally greater
All therapeutic applications remain investigational, and long-term human safety data are absent from the published literature
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