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Elevated BCAAs also link to chronic inflammation, with pro-inflammatory cytokines promoting IRS-1 serine phosphorylation (4)

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4.2 Autoimmune diseases Autoimmune diseases (AIDs) are a group of disorders in which the immune system develops an immune response to its own normal tissue components (189), characterized by chronic, systemic, and excessive immune activation and inflammation, ultimately leading to organ destruction or dysfunction (190)