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The precise mechanism of kidney-protective effects of GLP-1 RAs still remains elusive, but likely include direct kidney actions such as inducing natriuresis through NHE3 inhibition in the proximal tubules, suppressing the intrarenal renin-angiotensin system, ameliorating kidney ischemia/hypoxia [63, 64]
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Tirzepatide and Semaglutide are both in the class of drugs known as incretin mimetics or GLP-1 medications but have some differences
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