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Your metabolic rate decreases because you are now a smaller person requiring fewer calories

Cortisol sensitivity is higher

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Glucagon-like peptide-1 increases heart rate by a direct action on the sinus node, Cardiovascular Research (2024) Semaglutide and cardiovascular outcomes in obesity without diabetes, The New England Journal of Medicine (2023) Real-world safety profile of once-weekly semaglutide in people with type 2 diabetes: Analysis of pooled data from the SemaglUtide Real-world Evidence (SURE) programme, Diabetes, Obesity and Metabolism (2024) Ozempic (semaglutide injection) product monograph (2018) Tachycardia, Mayo Clinic (2023) How to check your heart rate (manually and using a device), Mass General Brigham (2025) Target Heart Rates Chart, American Heart Association (2025) Craig D

This guide walks through a simple, repeatable supplement routine for GLP-1 users who want to stay consistent