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In the brain, LC and ALC play important roles in cerebral bioenergetics and neuroprotection via a variety of mechanisms, including antioxidant properties, modulation and promotion of synaptic neurotransmission, particularly cholinergic neurotransmission, and their ability to enhance neuronal metabolism in mitochondria (Ahmed 2012)
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These SAR studies established the conformational basis for melanocortin receptor subtype selectivity and the design principle that cyclisation of the -MSH pharmacophore core produces central melanocortin receptor-preferential biology
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