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The CASTOR proteins are arginine sensors for the mTORC1 pathway
We analyzed the relationship between maintenance of weight loss and change in leptin-related parameters and found that increases in leptin and free leptin index during the weight loss maintenance period explained 46 and 48%, respectively, of the variation in weight increase in accordance with the previous studies
This is significantly more expensive than some other medications used for weight loss, including bupropion/naltrexone ($525 per month), orlistat ($300 per month), phentermine/topiramate (Qsymia
The question is no longer whether combining these therapies is biologically plausible
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