Indeed, numerous studies have reported the association between disrupted ROS homeostasis and disease progression, including cardiovascular diseases [23], neurodegenerative diseases [24], metabolic diseases [25], reproductive system diseases [26], digestive diseases [27], respiratory system diseases [28], cancers [29], inflammation [30] and infectious diseases [31]

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Theoretically, yes, through two mechanisms
The side effects we see in clinic are generally mild: transient injection site reaction, occasional mild nausea if starting at too high a dose, infrequent headache or lightheadedness in the first week