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And how do they work
The appeal of targeting specific inhibitors rather than broadly activating the pathway is selectivity: removing a specific brake in a specific tissue context is likely to produce more targeted effects than flooding the pathway with an upstream activating signal
It would be important to tease that out
The rate-limiting step in this process is the carnitine shuttle, specifically the CPT-I enzyme that attaches carnitine to long-chain fatty acids so they can cross the inner mitochondrial membrane
Those With Digestive Disorders Conditions like inflammatory bowel disease (IBD), Crohns disease, or other malabsorption syndromes reduce B12 absorption
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