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BDNF then activates TrkB receptors, triggering the PI3K/Akt and MAPK/ERK cascades that support neuronal survival, synaptogenesis, and synaptic plasticity

Loss of BBB integrity in AD may result in the entry of neurotoxic and pro-inflammatory molecules as well as a reduced clearance of -amyloid (A) that may invoke local inflammatory responses, and in turn initiate multiple pathways of neurodegeneration (Sweeney et al., 2018

In this sense, the two approaches are not necessarily competing

Coenzyme Q10 (CoQ10), which supports mitochondrial health and indirectly stabilizes telomere length through reduced oxidative stress

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