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Absolute contraindications to GLP-1 receptor agonists include: Personal history of medullary thyroid carcinoma Family history of medullary thyroid carcinoma Multiple Endocrine Neoplasia syndrome type 2 (MEN 2) Pregnancy (for weight management indications) Severe gastrointestinal disease, including gastroparesis Patients should be specifically questioned about these conditions during pre-treatment evaluation
Compounded tirzepatide works through the same slowed-gastric-emptying mechanism, so the same perioperative caution applies
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doi: 10.1136/bmj.39048.407928.BE 202
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