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Description

GLP-1-based therapies and the exocrine pancreas: more light, or just more heat

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A complex sequence of reactions begins with activation of toll-like receptor 4 (TLR4), a receptor for endotoxins, which leads to accumulation of the cyclooxygenase-2-derived lipoxin precursor 15-HETE esterified to the membrane phospholipids, especially phosphatidylinositol, a reaction that can be enhanced by aspirin treatment

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