Using the social isolation with chronic restraint rat model, we confirmed that trimetazidine (30 mg/kg) injected once-daily for 2 weeks had an antidepressant-like effect shown by reduced immobility in the forced swim test
Primer extension studies show that in liver, kidney, lung and placenta, the major transcription start sites are located 250 and 249 bp upstream of the translation start site and 100 bp upstream of the second major site, encoding a protein with 509 amino acids [16]
13 : 909916 Aureli T, Miccheli A, Ricciolini R, Di Cocco ME, Ramacci MT, Angelucci L et al
only 4% of subjects receiving placebo exhibited any HFF reduction
Coupled with our data, this observation suggests that GSH is critical for the steady state function of mitochondria, whose fitness is crucial for the maintenance of MZB