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For women whose weight gain lines up with hormonal shifts, over the counter options can support the effort, but they rarely solve the root cause

Available from www.training.cochrane.org/handbook

The GIP receptor activation brings its own party tricks to the table, improving insulin sensitivity and potentially enhancing fat metabolism in ways that GLP-1 alone cannot achieve

Lower estrogen levels reduce the amplifying effect on GLP-1 sensitivity, which may contribute to this modest difference