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For most healthy individuals the uncertain TMAO signal does not translate into a proven harm, but it is a reason to be cautious, to monitor health markers, and to favor products and doses aligned with human trial practice

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doi: 10.1016/j.envpol.2019.113357 85 TackJ.FriedM.HoughtonL

Theoretical concerns: angiogenic activity warrants caution in patients with active malignancy (no tumour-promoting effects observed in any preclinical study, but oncology populations have not been formally studied)

Del Turco S, Gaggini M, Daniele G, Basta G, Folli F, Sicari R, et al