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DAB staining, as indicated by the brown color in the immunohistochemistry analysis, was interpreted as positive expression (Figures 4A,B and see Supplementary Tables S11)
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Second, the preclinical models used may not fully recapitulate the metabolic and pharmacokinetic profiles of humans
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We developed a heterologous, recombinant modified vaccinia virus Ankara prime and adjuvanted protein boost vaccine, containing regulatory protein EE2 and major capsid protein
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