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Together, the cumulative effect on heart rate and blood pressure becomes clinically significant, particularly for patients with pre-existing cardiovascular disease, uncontrolled hypertension, or arrhythmias

The second is a review of new GLP-1 and related drugs currently in clinical trials that could treat a wide range of conditions

On the other hand, an increase in oxidative stress markers, including those associated with DNA damage, was observed in exposed animals, along with the induction of NF-kB dependent pro-inflammatory mediators: TNF-, IL-1, IL-6 and COX-2

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