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Passive diffusion allows roughly 1% to 2% of a massive oral dose to be absorbed directly across the mucosal lining, completely bypassing the need for stomach acid or Intrinsic Factor
Additionally, GLP-1RAs ameliorate DPN through various mechanisms, including the inhibition of inflammation, oxidative stress, and extracellular matrix remodeling, while simultaneously improving neural structure, function, and energy metabolism [11, 12, 30, 79,80,81,82,83,84,85,86]
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The findings improve our understanding of how increasingly prevalent GLP-1s may influence human behavior and identify new opportunities to potentially enhance treatment
