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Tirzepatide is the active ingredient in Mounjaro (for type 2 diabetes) and Zepbound (for weight loss)

SJS results in death in 10% of patients and in 30% for those with TEN due mostly to sepsis, acute respiratory distress syndrome and multiple organ failure

However, that does not mean peptides are risk-free

However, the protective effect was strongest in patients with obesity and absent in non-obese patients, strongly suggesting that benefits are heavily confounded by weight loss and metabolic improvement rather than direct gut anti-inflammation (101)

Research shows that variants in the GLP1R gene and related metabolic pathways create substantial individual differences in baseline GLP-1 secretion and appetite regulation capacity