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It is, however, well-known that the incidence and severity of hypertension are lower in females than in age-matched males due to the protective effects of estrogens, which beside acting on cardiovascular and renal systems, regulate the expression and secretion of AVP by the hypothalamic paraventricular nuclei ( In conclusion, in our study we demonstrated for the first time the existence in men of a close association between urinary hyaluronidase activity and vasopressinergic system activation, expressed by serum copeptin levels and urinary AQP2/creatinine ratio
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PMID 21623471
Nature (2014) 5
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