The corresponding placebo-group changes were small. The pooled Phase 3 analysis included more than 800 participants and confirmed a significant treatment effect on visceral adipose tissue. These results formed the basis of tesamorelins FDA-approved prescription indication
As an example, Zepbound (tirzepatide), is approved by the FDA for chronic weight management in adults with obesity (BMI of 30 kg/m2 or greater) or overweight (BMI of 27 kg/m2 or greater) with at least one weight-related condition, which can include conditions other than type 2 diabetes
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Therefore, this ratio is an indicator of mitochondrial function