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Annual transition probabilities were derived from event rates (r) using the declining exponential approximation of life expectancy (DEALE) formula [30]: While HbA1c serves as a validated surrogate endpoint for glucose-lowering medications and a well-established predictor of microvascular complications, the progression of T2DM and the development of its complications are driven by multiple interdependent risk factors
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The trial enrolled 120 adult participants with obesity or overweight (BMI 2738 kg/m) but without diabetes or significant comorbidities
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Research has shown that GLP-1 medications are associated with modest weight loss
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