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It is important to note that cells in the erythroid lineage can undergo a fully-fledged apoptosis [38] and other RCDs reported for nucleated cells, like necroptosis [65] and ferroptosis [40]
Cell Metab 15:675690
10,11,12 However, as negatively charged biological macromolecules, NADs have difficulty in crossing cellular membranes to enter cells
Conditions that result in red blood cell destruction, releasing a massive amount of free hemoglobin into the bloodstream, include: Infections by bacteria, parasites (malaria), and influenza virus [23]
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