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Other proposed contributors discussed in the literature include modulation of the dopaminergic and serotonergic systems, growth hormone receptor expression in fibroblasts, and interaction with the nitric oxide system at the level of vasomotor regulation (Sikiric et al., 2018)
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Clinical trials have found that the greatest improvement in haemoglobin A1c occurs within the first 24 weeks of treatment, after which levels stabilise
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