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Efficacy and Safety of GLP-1 Receptor Agonists, Dual Agonists, and Retatrutide for Weight Loss in Adults With Overweight or Obesity: A Bayesian NMA
Energy and nutrient intake: strong appetite reduction can lower protein, micronutrient and total-energy intake more than intended
The only clinically relevant difference between treatments was the higher frequency of gastrointestinal related adverse events with IcoSema versus icodec or semaglutide alone, which can be mitigated by appropriate dosing recommendations for IcoSema, as discussed above
Still, as with any investment, its important to consider some of the potential risks
8 Clinical trials have not shown that GIP reduces GLP-1 side effects
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