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Vuppalanchi R, Loomba R, Sanyal AJ, Nikooie A, Tang Y, Robins DA, Brouwers B, Hartman ML
One trial reported semaglutide (the active ingredient in Ozempic and Wegovy) was associated with a loss of fat-free mass (FFM) of up to 45.2% and liraglutide (the active ingredient in Victoza and Saxenda) with a loss of up to 60%, while tirzepatide (the active ingredient in Mounjaro and Zepbound) showed only 25.7%
[1] Lipid profiles provide valuable information about cardiovascular risk factors, which is relevant given that many patients with type 2 diabetes have dyslipidaemia
The primary outcome occurred in 9.2% of patients in the dapagliflozin group compared to 14.5% in the placebo group, results that were statistically significant
Therefore, deregulation of brain PI3 K/AKT is linked with the development of BIR and neuroinflammation and progression of AD neuropathology
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