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This low concentration of acetate is attributed to the intermolecular neutralization of the N-terminal amino group and the -amino group of lysine by carboxylate groups on the C-terminal or on the side chain of the aspartate and glutamate residues
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see also NSW S4D listing)
In states of obesity and metabolic dysfunction, NNMT is often overexpressed in adipose tissue, depleting nicotinamide and reducing NAD+ availability [2]
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