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Eli Lilly Positioning: Eli Lilly is a close competitor to Novo Nordisk, with its flagship GLP-1 receptor agonist Trulicity (dulaglutide) used for type 2 diabetes

Theres also early, preliminary interest in roles for brain energy metabolism

Glossary 5-ASA 5-aminosalicylic acid UC ulcerative colitis TCM traditional Chinese medicine NF-B nuclear factor kappa-light-chain-enhancer of activated B cells MAPK mitogen-activated protein kinase ERK extracellular signal-regulated kinase TNF- tumor necrosis factor-alpha IL interleukin (e.g., IL-1, IL-4, IL-6, IL-8, IL-10) CRP C-reactive protein Hs-CRP high-sensitivity C-reactive protein DAI disease activity index MHC-II major histocompatibility complex class II STAT signal transducer and activator of transcription (e.g., STAT3, STAT6) Th T helper cell (e.g., Th1, Th2) CB cannabinoid receptor (e.g., CB1, CB2) GPR35 G protein-coupled receptor 35 sIgA secretory immunoglobulin A SCFAs short-chain fatty acids MUC-2 mucin 2 ZO-1 zonula occludens-1 TLR Toll-like receptor MDA malondialdehyde SOD superoxide dismutase GPx glutathione peroxidase GSH glutathione ROS reactive oxygen species MPO myeloperoxidase LPS lipopolysaccharide MMP-9 matrix metalloproteinase-9 eNOS endothelial nitric oxide synthase VEGF vascular endothelial growth factor PLT platelets MPV mean platelet volume IPA indole-3-propionic acid IAA indole-3-acetic acid AhR aryl hydrocarbon receptor PXR pregnane X receptor BDNF brain-derived neurotrophic factor TrkB tropomyosin receptor kinase B p75NTR p75 neurotrophin receptor RCT randomized controlled trial GI gastrointestinal References 1 Ahmed NajarI.SharmaA.AlshammariA.AlbekairiT

doi: 10.1159/000368833 40 SuganamiTNishidaJOgawaY

GLP-1 produces continued, compounding loss