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Neuroscience & Biobehavioral Reviews, 114, 134-155

Its unique pharmacodynamic profile as a partial -opioid receptor agonist and -opioid receptor antagonist provides both efficacy and an improved safety margin relative to full opioid agonists

The novel pentapeptide-selective ghrelin agonist relamorelin (RM-131) has similar characteristics to native ghrelin, but with a 100-fold greater potency to reverse gastric ileus in animal models and a longer plasma half-life

By effectively managing conditions such as type 2 diabetes, cardiovascular disease, and metabolic syndrome, retatrutide has the potential to transform lives and reduce the burden of obesity-related comorbidities

This indicates high public interest in GLP-1 RAs and highlights priorities for clinical and policy communities, including monitoring side effects, addressing access barriers, and acknowledging both the physical and psychological benefits of these drugs