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Additionally, GLP-1 slows down the rate at which the stomach empties, leading to prolonged feelings of fullness and reduced appetite

Among the GLP-1 RAs and a dual GLP-1/GIP RA, exenatide has the most developed pharmacokinetic model (9 of 30), 61,177184 followed by semaglutide (8 of 30), 68,162,182,185189 liraglutide and dulaglutide (each 5 of 30), 156,177,182,189194 and tirzepatide (3 of 30)

In those, loss of NRF2 resulted in a more rapid onset and more severe clinical course of the EAE model, which was accompanied by increased glial activation, exacerbated spinal cord damage, and axonal degeneration as well as increased levels of proinflammatory cytokines (Johnson et al., 2010