doi: 10.1172/JCI146353 Summary Keywords GIP, GLP-1, tirzepatide, basal insulin, type 2 diabetes, obesity, body weight, hypoglycemia Citation Lisco G, De Tullio A, Disoteo O, De Geronimo V, Piazzolla G, De Pergola G, Giagulli VA, Jirillo E, Guastamacchia E, Sabb C and Triggiani V (2022) Basal insulin intensification with GLP-1RA and dual GIP and GLP-1RA in patients with uncontrolled type 2 diabetes mellitus: A rapid review of randomized controlled trials and meta-analysis
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The most widely known GLP-1 medications include semaglutide and tirzepatide, sold under brand names such as Wegovy, Ozempic, and Mounjaro
This difference in subjective effects was not explained by an increase in nausea in the GLP-1RA group
More recent meta-analyses confirm that digital self-monitoring, delivered via apps, wearables, or electronic scales, produces moderate weight loss and improves adherence compared to paper-based approaches, with higher engagement linked to greater weight reduction [91, 92]