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To attain the health benefits conferred by GLP-1s, it is critical that people prescribed GLP-1s continue to take them at least long enough to realize clinical success, and preferably longer to avoid possible weight rebound once they come off the medications
GLP-1 receptor agonists have a sustained stimulatory effect on corticosterone release after chronic treatment
Start low (1 gram daily) to assess tolerance, then increase gradually if needed
For these patients, the goal of personalization is to prescribe just enough medication to achieve targeted results but not so much that the cure feels worse than the disease
