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The damage from freeze-thaw cycles comes from repeated freezing and thawing of the same solution, where ice crystals form, melt, reform, and melt again, each cycle physically stressing the peptide molecules
Fisher SJ, Damsky CH
Many respond poorly even to 500mcg daily, potentially requiring synthetic growth hormone replacement instead if treatment indicated
While the exact cause of rosacea is unknown, an overactive immune system is thought to play a role
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