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Some potential causes of dark inner thighs include: dry skin too much sun exposure chafing from the thighs rubbing together while walking or exercising skin pigment conditions, such as acanthosis nigricans use of certain medications Because some of the potential causes of dark inner thighs are conditions that require treatment, a person should speak to a doctor if they are unsure what the cause is

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196 When tumor cells metastasize to distant sites through the circulatory system, they are exposed to severe stress within the blood vessels, such as hemodynamic shear forces and attacks of the immune system