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Katsurada K, Maejima Y, Nakata M, Kodaira M, Suyama S
Como os ossos se adaptam ao peso que suportam, perder peso significa menos estresse sobre o esqueleto e, com o tempo, isso pode levar a pequenas redues na resistncia ssea
Rapid weight loss without adequate protein intake, resistance training, mobility work, and structured follow-up may increase the risk of lean tissue loss, tendon overload, frailty, and downstream musculoskeletal complications
Although these studies were carried out in rat models, they once again highlight the small intestine as a site of action of metformin, and suggest a novel pathway through which metformin may be acting
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