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In another phase II study, a fixed combination of a long-acting analogue of the islet peptide amylin (cagrilintide) with semaglutide at 2.4 mg (cagrisema) produced weight losses of 15.5% and 2.18% reductions in HbA 1c in obese individuals with T2DM [44]
They are a fantastic bridge, but they may not be a permanent solution
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Current evidence suggests improvements are likely indirect through metabolic changes, although direct testicular effects are still under study
It lowers drive to eat
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