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Published 2014 Nov 18
The opposing effects of GIP and GLP-1 on lipogenesis and lipolysis, respectively, help maintain adipocytes in young and healthy state, fostering higher levels of adiponectin a key adipokine known for its potential antidiabetic, anti-inflammatory, and antiatherogenic properties (185)
Notably, indel frequencies at the top 10 off-target sites were minimal, suggesting a low genomic safety risk (Supplementary Fig
While not FDA-approved individually, they follow strict safety and quality standards
The main goal of the company is to advance the treatment of T2D by addressing the root cause of the disease, rather than targeting high blood-sugar levels, a well-recognized primary symptom of the disease
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