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Cardiovascular outcome trials of tirzepatideSURPASS-CVOT and SUMMIThave shown encouraging signals, with SURPASS-CVOT meeting the prespecified criteria for non-inferiority for MACEs and a 16% reduction in all-cause mortality [86]

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Metformin may help some people reduce their appetite, but this effect is not consistent for everyone

For those with a history of high blood sugar, the sudden control over glucose levels might even lead to a slight initial increase in urination, as the kidneys adjust to processing a more normal level of sugar

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