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However, the contribution of GLP-1 to insulin stimulation was likely modest, and further evaluation using a GLP-1 receptor antagonist would be necessary

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One-way analysis of variance (ANOVA) was used to compare normally distributed data, while a KruskalWallis test was used to compare non-normally distributed data between groups

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These include: Nausea (the most common complaint, particularly during dose escalation) Vomiting Diarrhoea Constipation Decreased appetite These effects are generally dose-dependent and tend to be most pronounced during the initial weeks of treatment or following a dose increase