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J Appl Anim Res 42:166176 Jasek-Gajda E, Jurkowska H, Jasinska M, Lis GJ (2020) Targeting the MAPK/ERK and PI3K/AKT signaling pathways affects NRF2, Trx and GSH antioxidant systems in leukemia cells
These topics should always be understood in a controlled, non-clinical context
More research is needed before recommending spermidine-rich or polyamine-modified diets to individuals with existing malignancies 21 , 135
Important safety considerations include a boxed warning for medullary thyroid carcinoma risk (contraindicated in patients with MEN2 or family history of MTC), pancreatitis risk, gallbladder disease, and potential for dehydration
This information helps your provider decide whether to maintain the current dose or begin dose escalation at the next scheduled adjustment
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