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Mucolytics for acute exacerbations of chronic obstructive pulmonary disease: a meta-analysis
The mechanism involves upregulation of tissue inhibitors of metalloproteinases (TIMPs) and simultaneous downregulation of matrix metalloproteinases (MMPs), shifting the extracellular matrix balance toward net deposition rather than degradation
CagianelliMAAndreiniRet al
The submission requirement will apply to covered studies whose enrollment begins 180 days after FDA publishes final guidance
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