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UK dosing schedules, per BNF and NICE CKS, are as follows: Without neurological involvement: 1 mg IM three times a week for 2 weeks, then 1 mg IM every 23 months [14] [15] With neurological involvement: 1 mg IM on alternate days until no further improvement, then 1 mg IM every 2 months Patients should not self-initiate supplementation without first discussing it with their GP or prescribing clinician

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