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Scaffold-based methods introduce a porous matrixnatural (collagen, gelatin, fibronectin) or synthetic (PLGA)to direct cell survival and vessel ingrowth, which can mitigate early necrosis but complicate manufacture and regulatory review

Both medications are contraindicated in people with a personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2 (MEN 2)

2024 Feb 19;69:102475

In a pooled analysis of data from 17 clinical trials and six extension studies with empagliflozin, the incidence of events consistent with UTI was similar for placebo and empagliflozin 10 and 25 mg (11.3, 10.4, and 9.4/100 patient-years, respectively) [67]

doi: 10.1016/j.atherosclerosis.2017.04.001 131 PoulterNRPrabhakaranDCaulfieldM