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To mitigate potential discrepancies in baseline characteristics between the two study groups, we comprehensively integrated and algorithmically selected high-dimensional covariates assessed within 1 year before the index time

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Short-chain fatty acids were demonstrated not only to reach the bloodstream but also to cross the bloodbrain barrier (BBB) and alter the hypothalamic leptin and adiponectin gene expression (170, 171)

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[1] [14] L-Carnitine, acetyl-l-carnitine, and propionyl-l-carnitine are available in dietary supplement pills or powders, with a daily amount of 0.5 to 1 g considered to be safe