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doi: 10.1016/j.abb.2022.109347 228 ZhangXQDongJJCaiTShenXZhouXJLiaoL
The mechanism by which epitalon stimulates pineal melatonin production is not fully elucidated, but may involve activation of genes encoding enzymes in the melatonin biosynthetic pathway (particularly N-acetyltransferase, the rate-limiting enzyme for melatonin synthesis) or restoration of pineal cell function in aging tissue
Shiraishi, D
The range of skin pigmentation observed in humans is an apparent adaptation to UVR levels differing by latitude
Pisano C, Pratesi G, Laccabue D, et al
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