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There were also limited interactions between GH5 subunit and helix 8 of the receptor (E392 GH5 , N440 8.47b and G441 8.48b )

The in vivo half-life study in hemizygous human FcRn Tg32 mice was performed at The Jackson Laboratory (JAX Services, Bar Harbor, ME, USA), which was approved by the Animal Care and Use Committee at The Jackson Laboratory